Systematic reviews and meta-analyses: a step-by-step guide

If you are considering doing a systematic review or meta-analysis, this step-by-step guide aims to support you along the way. It explains the background to these methodologies, what is involved, and how to get started, keep going, and finish!

It will direct you to useful resources provided by CCACE researchers and external bodies. There is a ‘wiki’ section for you, and others who have been through the process, to add useful hints and tips, and up-to-date resources particularly relevant to researchers and students in CCACE.


What is a systematic review or meta-analysis?

A systematic review answers a defined research question by collecting and summarising all empirical evidence that fits pre-specified eligibility criteria.

A meta-analysis is the use of statistical methods to summarise the results of these studies.

Systematic reviews, just like other research articles, can be of varying quality. They are a significant piece of work (the Centre for Reviews and Dissemination at York estimates that a team will take 9-24 months), and to be useful to other researchers and practitioners they should have:

  • clearly stated objectives with pre-defined eligibility criteria for studies
  • explicit, reproducible methodology
  • a systematic search that attempts to identify all studies
  • assessment of the validity of the findings of the included studies (e.g. risk of bias)
  • systematic presentation, and synthesis, of the characteristics and findings of the included studies


It is essential that each review is approached rigorously and with careful attention to detail. Plan carefully, and document everything. The consensus reporting guidelines for different study designs proposed by EQUATOR ( are a useful starting point. PRISMA provides guidance on what you should include when reporting a systematic review.

Step 1: Why do a systematic review?  Click here

Step 2: Who will be involved? Click here

Step 3: Formulate the problem. Has it been done before? Registering your review. Click here

Step 4: Perform your search. Click here

Step 5: Data extraction. Click here

Step 6: Critical appraisal of studies (quality assessment). Click here

Step 7 Data synthesis. Click here

Step 8: Presenting results (writing the report). Click here

Step 9: Archiving and updating. Click here


Useful Resources:  Click here

Note: If you have any useful resources that would be beneficial for this guide, please let us know (contact Beverly Roberts, and she'll add them here.


Useful Lectures:

Lecture 1: Introduction to systematic reviews  

Lecture 2: Systematic literature searching

Lecture 3: Data extraction, quality assessment and narrative synthesis

Lecture 4: Systematic review hints and tips

Lecture 5: Introduction to meta-analysis


Acknowledgements and References

Much of this advice is based on the excellent (and extensive) guidance from the Cochrane Collaboration ( ) and the Centre for Reviews and Dissemination at York (!SSL!/WebHelp/SysRev3.htm). If you are proposing to perform a systematic review these provide invaluable detailed advice, and useful examples.